To face the challenges of the pharmaceutical industry, hazardous reactions in chemical development and synthesis of new chemical entities are one possible approach to access specific drugs, reduce costs, and improve purity.
Hazardous chemistry accomplished at DOTTIKON EXCLUSIVE SYNTHESIS comprises four categories
highly exothermic processes, thermally or mechanically unstable compounds, highly reactive compounds and high-potent compounds (HAPIs).
Within these categories DOTTIKON ES performs hazardous reactions in cGMP quality.
DOTTIKON ES has profound and specialized experience in hazardous reactions
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History of over 90 years with exothermal reactions |
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14 established methods for gathering safety-critical data |
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Dedicated equipment |
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Broad experience in scale-up of hazardous processes like special nitrations, oxidations and azide chemistry |
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Equipped to handle hazardous reactions and reagents such as |
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Azide chemistry (sodium azide DPPA) |
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Bromination (bromine, PBr-compounds, NBS) |
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Chlorination (chlorine, thionyl- and sulfuryl chloride, phosphorous chloride, NCS) |
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Cyanation (sodium cyanide) |
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Dehydration (phosphorous pentoxide) |
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Diazotation (nitrous acid) |
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Hydrazine chemistry (hydrazine hydrate and alkylhydrazines) |
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Hydride reduction (LAH, AIH2R2, borohydrides, NaH) |
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Iodation (iodine, iodides) |
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Methylation (dimethylsulfate, methyliodide) |
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Nitration (concentrated nitric acid and nitric/sulfuric acid mixtures, acetic acid) |
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Nitroaldol reaction (nitromethane, nitroethane) |
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Organometallic chemistry (Grignard, alkyllithium compounds) |
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Oxidation (nitric acid, peroxides) |
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Peroxidation (H2O2, peracids, Bayer-Villiger reaction) |
