"Calo 2310" calorimeter. One of our special equipment.

Hazardous Reactions

In order to face the challenges of the pharmaceutical industry today, hazardous reactions in chemical development and synthesis of new chemical entities are one possible approach to innovate more specific specialty drugs and reduce costs, while improving impurity profiles.

Hazardous chemistry accomplished at DOTTIKON EXCLUSIVE SYNTHESIS comprise of four categories: highly exothermic processes, thermally or mechanically unstable compounds, highly reactive compounds and high-potent compounds. Within these categories DOTTIKON ES performs hazardous reactions in cGMP quality.

DOTTIKON ES has a profound specialized experience in hazardous reactions.
  History of over 90 years with exothermal reactions
  14 established methods for gathering safety-critical data
  Dedicated equipment
  Broad experience in scale up of hazardous processes like special nitrations, oxidations and azide chemistry
  Equiped to handle hazardous reactions and reagents
    Azide chemistry (sodium azide)
    Bromination (bromine, PBr-compounds, NBS)
    Chlorination (chlorine, thionyl- and sulfuryl chloride, phosphorous chloride, NCS)
    Cyanation (sodium cyanide)
    Dehydration (phosphorous pentoxide)
    Diazotation (nitrous acid)
    Hydrazine chemistry (hydrazine hydrate and alkylhydrazines)
    Hydride reduction (LAH, AIH2R2, borohydrides, NaH)
    Iodation (iodine, iodides)
    Methylation (dimethylsulfate, methyliodide)
    Nitration (concentrated nitric acid and nitric/sulfuric acid mixtures, acetic acid)
    Nitroaldol reaction (nitromethane, nitroethane)
    Organometallic chemistry (Grignard, alkyl-lithium-compounds)
    Oxidation (nitric acid, peroxides)
    Peroxydation (H2O2, peracids, Baeyer Villiger reaction)



Specialist for Hazardous Reactions: PDF File

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